Alltop RSS http://wry999.alltop.com Alltop RSS feed for wry999.alltop.com en-us http://westallen.typepad.com/brains_on_purpose/2012/02/good-review-of-the-tome-.html Good review of the tome MASTER AND HIS EMISSARY, an antidote to left-brain, right-brain mythology http://westallen.typepad.com/brains_on_purpose/2012/02/good-review-of-the-tome-.html http://psychcentral.com/blog/archives/2012/02/09/google-pulls-the-plug-on-superpoke-pets-players-sue/ Google Pulls the Plug on SuperPoke Pets, Players Sue http://psychcentral.com/blog/archives/2012/02/09/google-pulls-the-plug-on-superpoke-pets-players-sue/ http://www.sciencedaily.com/releases/2012/02/120209102007.htm Right hand or left? How the brain solves a perceptual puzzle http://www.sciencedaily.com/releases/2012/02/120209102007.htm http://feedproxy.google.com/%7Er/SharpBrains/%7E3/4pNRcIFfA-0/ Enhance Metacognition and Problem-Solving by Talking Out Loud to Yourself http://feedproxy.google.com/%7Er/SharpBrains/%7E3/4pNRcIFfA-0/ http://rss.sciam.com/click.phdo?i=4a3ad703f72ac3d07021525552426481 An Archival Treasure: Singing Mice http://rss.sciam.com/click.phdo?i=4a3ad703f72ac3d07021525552426481 The recent talk of ultrasonic tarsiers reminded me of a post I wrote a couple years ago. You see, tarsiers aren’t the only animal to communicate at a sound frequency beyond the level of human hearing: mice do as well. But, for some reason, some mice actually chatter in such a way that they can be heard by humans. While most mice are ultrasonic , as far as I can tell there’s no good explanation for why some mice are…sonic. But this story begins one hundred years ago, in 1912, likely well before anyone knew about ultrasonic communication in mice.

Sometimes, when trolling through your institution’s journal subscriptions online, you wander into a treasure trove. I happened upon such a treasure trove recently: The Journal of Animal Behavior , which was published for just six years, between 1911 and 1916.

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http://brainblogger.com/2012/02/09/aging-intelligently/ Aging Intelligently http://brainblogger.com/2012/02/09/aging-intelligently/ http://rss.sciam.com/click.phdo?i=e70d7000131c66374cbd153e7ba86596 Why Your Romantic Partner Annoys You (preview) http://rss.sciam.com/click.phdo?i=e70d7000131c66374cbd153e7ba86596 Excerpted with permission of the publisher John Wiley & Sons, Inc., from Annoying: The Science of What Bugs Us , by Joe Palca and Flora Lichtman. Copyright © 2011 by Joe Palca and Flora Lichtman. This book is available at all bookstores, online booksellers and the Wiley Web site at www.wiley.com , or call 1-800-225-5945.

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http://psychcentral.com/blog/archives/2012/02/09/is-it-time-to-start-dating-your-spouse/ Is It Time to Start Dating Your Spouse? http://psychcentral.com/blog/archives/2012/02/09/is-it-time-to-start-dating-your-spouse/ http://www.medicalnewstoday.com/releases/241342.php New Smartphone, A Virtual Therapist And Other Novel Technologies To Treat Depression http://www.medicalnewstoday.com/releases/241342.php http://www.medicalnewstoday.com/releases/241339.php Studying Communication Within The Brain With Cutting-Edge MRI Techniques http://www.medicalnewstoday.com/releases/241339.php http://www.medicalnewstoday.com/releases/241346.php The Brain's Quick Interceptions Help You Navigate The World http://www.medicalnewstoday.com/releases/241346.php http://www.medicalnewstoday.com/releases/241349.php Child Sex Abuse Victims Blamed More By Parents If Perpetrator Is Another Youth http://www.medicalnewstoday.com/releases/241349.php http://www.medicalnewstoday.com/releases/241338.php Facebook Use Elevates Mood http://www.medicalnewstoday.com/releases/241338.php http://www.medicalnewstoday.com/releases/241316.php New Study: The Dark Path To Antisocial Personality Disorder http://www.medicalnewstoday.com/releases/241316.php http://www.medicalnewstoday.com/articles/241373.php Lab-Made Neurons Allow Scientists To Study A Genetic Cause Of Parkinson's http://www.medicalnewstoday.com/articles/241373.php http://www.medicalnewstoday.com/releases/241319.php Head, Neck Impacts Accumulate Fastest In Fighters Who Don't Wear Headgear http://www.medicalnewstoday.com/releases/241319.php http://www.medicalnewstoday.com/releases/241315.php The Health Impacts Of Comparing Yourself To Others http://www.medicalnewstoday.com/releases/241315.php http://www.medicalnewstoday.com/releases/241317.php Why The Middle Finger Has Such A Slow Connection http://www.medicalnewstoday.com/releases/241317.php http://www.psychologytoday.com/collections/201202/reading-the-opposite-sex Reading The Opposite Sex http://www.psychologytoday.com/collections/201202/reading-the-opposite-sex
Can men and women ever understand each other?
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http://rss.sciam.com/click.phdo?i=31e9a3aa6f4cbc1639e170e9f4b3128a #SciAmBlogs Wednesday - psilocybin, Brighton octopus, gorillas, tarsiers, gonorrhea and more. http://rss.sciam.com/click.phdo?i=31e9a3aa6f4cbc1639e170e9f4b3128a There are two new podcasts about ScienceOnline2012 – ScienceOnline2012 Recap Feb. 7 at UW School of Aquatic Fishery Sciences and Science… sort of – Episode 122: Finding a New Course .

- Scicurious – This is your brain on psilocybin

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http://rss.sciam.com/click.phdo?i=842dd2f81ef6f896105e1c12aae16305 Tiny, Tree-Dwelling Primate Called Tarsier Sends and Receives Ultrasonic Calls http://rss.sciam.com/click.phdo?i=842dd2f81ef6f896105e1c12aae16305 The Philippine tarsier (Tarsius syrichta) makes ultrasonic calls. (Credit: Nathaniel Dominy, Dartmouth)

Let’s be honest: tarsiers look odd. Among the smallest of all primates, most species of tarsier would fit easily in the palm of your hand. They have long, slender, largely hairless tails and elongated fingers with knobby knuckles and mushroom-cap finger pads.

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http://www.sciencedaily.com/releases/2012/02/120208180057.htm Memory strengthened by stimulating key site in brain http://www.sciencedaily.com/releases/2012/02/120208180057.htm http://www.sciencedaily.com/releases/2012/02/120208152252.htm Gene therapy for inherited blindness succeeds in patients' other eye http://www.sciencedaily.com/releases/2012/02/120208152252.htm http://www.sciencedaily.com/releases/2012/02/120208145955.htm Sound rather than sight can activate 'seeing' for the blind, say researchers http://www.sciencedaily.com/releases/2012/02/120208145955.htm http://feedproxy.google.com/%7Er/SharpBrains/%7E3/N9hwxcy8wX4/ Save the Date: 2012 SharpBrains Summit — Optimizing Health Through Neuroplasticity-Driven Innovation http://feedproxy.google.com/%7Er/SharpBrains/%7E3/N9hwxcy8wX4/ http://feeds.b5media.com/%7Er/b5media/MentalHealthNotes/%7E3/9YX8RUbeh_Q/ Watch Michelle Obama Adorably Beats Jimmy Fallon In Tug-Of-War, Push-Ups http://feeds.b5media.com/%7Er/b5media/MentalHealthNotes/%7E3/9YX8RUbeh_Q/ Michelle Obama has been all over the talk show circuit in the last few weeks, promoting the "Let's Move" campaign, her champion cause to end childhood obesity in the United States...and proving that she's basically a fitness bad-ass. But last night, it reached an apex of awesomeness, when she invited Jimmy Fallon to the White House for some hula hooping and potato sack races. Adorableness and inspiration ensued. More »

Post from: Blisstree

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http://rss.sciam.com/click.phdo?i=7f092a94c8e82d65db5e9c5dd89a4864 Sight Seen: Gene Therapy Restores Vision in Both Eyes http://rss.sciam.com/click.phdo?i=7f092a94c8e82d65db5e9c5dd89a4864 Gene therapy has markedly improved vision in both eyes in three women who were born virtually blind. The patients can now avoid obstacles even in dim light, read large print and recognize people's faces. The operation, researchers predict, should work even better in children and adolescents blinded by the same condition.

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http://www.sciencedaily.com/releases/2012/02/120208133037.htm Study to determine whether fish oil can help prevent psychiatric disorders http://www.sciencedaily.com/releases/2012/02/120208133037.htm http://www.sciencedaily.com/releases/2012/02/120208132721.htm Flipping a light switch in the cell: Quantum dots used for targeted neural activation http://www.sciencedaily.com/releases/2012/02/120208132721.htm http://www.sciencedaily.com/releases/2012/02/120208132709.htm Physical activity yields feelings of excitement, enthusiasm http://www.sciencedaily.com/releases/2012/02/120208132709.htm http://www.medicalnewstoday.com/articles/241369.php Football Withdrawal Coping Tips http://www.medicalnewstoday.com/articles/241369.php http://psychcentral.com/blog/archives/2012/02/08/video-recovering-from-cheating/ Video: Recovering from Cheating http://psychcentral.com/blog/archives/2012/02/08/video-recovering-from-cheating/ http://psychcentral.com/blog/archives/2012/02/08/interview-with-margarita-tartakovsky/ Interview with Margarita Tartakovsky http://psychcentral.com/blog/archives/2012/02/08/interview-with-margarita-tartakovsky/ http://www.psychologytoday.com/collections/201202/seeking-solitude Seeking Solitude http://www.psychologytoday.com/collections/201202/seeking-solitude
The necessary art of alone time.
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http://web.mit.edu/newsoffice/2012/brain-waves-energy-0208.html Neuroscientists link brain-wave pattern to energy consumption http://web.mit.edu/newsoffice/2012/brain-waves-energy-0208.html
Emery Brown, an MIT professor of brain and cognitive sciences and health sciences and technology, left, and ShiNung Ching, a postdoc in Brown’s lab.
Photo: M. Scott Brauer
Different brain states produce different waves of electrical activity, with the alert brain, relaxed brain and sleeping brain producing easily distinguishable electroencephalogram (EEG) patterns. These patterns change even more dramatically when the brain goes into certain deeply quiescent states during general anesthesia or a coma.

MIT and Harvard University researchers have now figured out how one such quiescent state, known as burst suppression, arises. The finding, reported in the online edition of the Proceedings of the National Academy of Sciences the week of Feb. 6, could help researchers better monitor other states in which burst suppression occurs. For example, it is also seen in the brains of heart attack victims who are cooled to prevent brain damage due to oxygen deprivation, and in the brains of patients deliberately placed into a medical coma to treat a traumatic brain injury or intractable seizures.

During burst suppression, the brain is quiet for up to several seconds at a time, punctuated by short bursts of activity. Emery Brown, an MIT professor of brain and cognitive sciences and health sciences and technology and an anesthesiologist at Massachusetts General Hospital, set out to study burst suppression in the anesthetized brain and other brain states in hopes of discovering a fundamental mechanism for how the pattern arises. Such knowledge could help scientists figure out how much burst suppression is needed for optimal brain protection during induced hypothermia, when this state is created deliberately.

“You might be able to develop a much more principled way to guide therapy for using burst suppression in cases of medical coma,” says Brown, senior author of the PNAS paper. “The question is, how do you know that patients are sufficiently brain-protected? Should they have one burst every second? Or one every five seconds?”

Modeling electrical activity

ShiNung Ching, a postdoc in Brown’s lab and lead author of the PNAS paper, developed a model to describe how burst suppression arises, based on the behavior of neurons in the brain. Neuron firing is controlled by the activity of channels that allow ions such as potassium and sodium to flow in and out of the cell, altering its voltage.

For each neuron, “we’re able to mathematically model the flow of ions into and out of the cell body, through the membrane,” Ching says. In this study, the team combined many neurons to create a model of a large brain network. By showing how both cooling and certain anesthetic drugs reduce the brain’s use of ATP (the cell’s energy currency), the researchers were able to generate burst-suppression patterns consistent with those actually seen in human patients.

This is the first time that reductions in metabolic activity at the neuron level have been linked to burst suppression, and suggests that the brain likely uses burst suppression to conserve vital energy during times of trauma.

“What’s really exciting about this is the idea that the metabolic regulation of cell energy stores plays a role in the observed dynamics of EEG. That’s a different way to think about the determinants of EEG,” says Nicholas Schiff, a professor of neurology and neuroscience at Weill Cornell Medical College who was not involved in this research.

The developing brain

Burst suppression is also seen in babies born prematurely. As these babies get older, their brain patterns move into the normal continuous pattern. Brown speculates that in premature infants, the brain may be protecting itself by conserving energy.

“When you’re looking at these kids develop, we can easily start to suggest ways of tracking their improvement quantitatively. So the same algorithms we use to track burst suppression in the operating room could be used to track the disappearance of burst suppression in these kids,” Brown says.

Such tracking could help doctors determine whether premature infants are moving toward normal development or have an underlying brain disorder that might otherwise go undiagnosed, Ching says.

In future studies, the researchers plan to study premature infants as well as patients whose brains are cooled and those in induced comas. Such studies could reveal just how much burst suppression is enough to protect the brain in those vulnerable situations.
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http://feedproxy.google.com/%7Er/SharpBrains/%7E3/ApXVnk9CFYY/ Diagnosing early Alzheimer’s and Mild Cognitive Impairment: Emerging Challenges and Implications http://feedproxy.google.com/%7Er/SharpBrains/%7E3/ApXVnk9CFYY/ http://westallen.typepad.com/brains_on_purpose/2012/02/love-is-more-than-just-chocolate.html Valentine's Day news: Love is more than just chemicals in the brain--P.S. So is conflict http://westallen.typepad.com/brains_on_purpose/2012/02/love-is-more-than-just-chocolate.html http://feeds.b5media.com/%7Er/b5media/MentalHealthNotes/%7E3/wd0nME7ZVFQ/ Studies Prove Facebook Is Like 5th Grade Gym Class All Over Again http://feeds.b5media.com/%7Er/b5media/MentalHealthNotes/%7E3/wd0nME7ZVFQ/ Facebook often feels like gym class in elementary school to me. It has all the same scenarios, really: Friends and activities that boost our self-esteem and well-being, and others who just make us feel like we're the last one picked for the kickball team all over again. More »

Post from: Blisstree

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http://psychcentral.com/blog/archives/2012/02/07/why-do-we-care-what-others-think/ Why Do We Care What Others Think? http://psychcentral.com/blog/archives/2012/02/07/why-do-we-care-what-others-think/ http://feeds.b5media.com/%7Er/b5media/MentalHealthNotes/%7E3/Kxx1JNugCIo/ My Therapist Is Pregnant, And I Hate Her For It http://feeds.b5media.com/%7Er/b5media/MentalHealthNotes/%7E3/Kxx1JNugCIo/ More »

Post from: Blisstree

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http://www.medicalnewstoday.com/releases/241251.php New Analysis Finds No Antidepressant-Suicide Link In Youths http://www.medicalnewstoday.com/releases/241251.php http://www.psychologytoday.com/collections/201202/would-you-be-your-own-friend Would You Be Your Own Friend? http://www.psychologytoday.com/collections/201202/would-you-be-your-own-friend
We're often blind to the not-so-wonderful traits we possess—but quick to point them out in others.
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http://web.mit.edu/newsoffice/2012/connectome-0207.html My connectome, myself http://web.mit.edu/newsoffice/2012/connectome-0207.html
Mapping all those connections may sound like a daunting task, but MIT neuroscientist Sebastian Seung believes it can be done — one cubic millimeter of brain tissue at a time.

“When you start to explain how difficult it would be to find the connectome of an entire brain, people ask, ‘What’s the point? That seems too far off.’ But even finding or mapping the connections in a small piece of brain can tell you a lot,” says Seung, a professor of computational neuroscience and physics at MIT.

Even more than our genome, our connectome shapes who we are, says Seung, who outlines his vision for connectome research in a new book, Connectome, published this month by Houghton Mifflin Harcourt. “Clearly genes are very important, but because they don’t change after the moment of conception, they can’t really account for the effects of experience,” he says.

A streambed of consciousness

Seung envisions the brain’s connections as the “streambed” through which our consciousness flows. At a molecular level, that streambed consists of billions of synapses, in which one neuron sends signals to the next via chemical neurotransmitters. While scientists once believed that synapses could not be changed after formation, they now know that synapses are continuously strengthening, weakening, disappearing and reforming, as we learn new things and have new experiences.

While neuroscientists have long hypothesized that the key to our unique selves lies in those connections, this has proven impossible to test because the technology to map the connections did not exist. That is now changing, due to the efforts of Seung and a handful of other neuroscientists around the world.

At the Max Planck Institute for Medical Research in Heidelberg, Germany, neuroscientists in the laboratory of Winfried Denk have taken extremely thin slices of brain tissue and generated electron-microscope images of all the neural connections within each slice. Similar high-resolution images are being acquired in the laboratory of Jeff Lichtman at Harvard University. However, the next step — mapping those connections — is extremely time-consuming. Seung estimates that it would take 100,000 years for a lone worker to trace the connections in one cubic millimeter of brain tissue.

To help speed that up, Seung and his colleagues have developed an artificial intelligence (AI) system, which they presented at the International Conference on Computer Vision and the Neural Information Processing Systems Conference in 2009. However, the system still requires human guidance, so the researchers are enlisting the help of the general public through a website called eyewire.org. “The brain is like a vast jungle of neurons,” Seung says. “They’re like trees that are all tangled up together, and people can help us explore that.”

Participants in the Eyewire project will help guide the computer program when it loses track of where a neuronal extension goes amidst the tangle of neurons.

“The person can click the mouse and say color here, and the computer starts coloring again, and keeps going, and then stops again when it’s uncertain. So you’re guiding the computer,” Seung says. Furthermore, the AI system becomes “smarter” as people guide it, so it will need less and less help as it goes on.

Rather than tackling the human brain right away, the researchers are beginning with a 300- by 350- by 80-micron slice of mouse retinal tissue. Images of just this small piece of tissue take up a terabyte of data, or enough to hold 220 million pages of text.

In a review published in New Scientist, Terrence Sejnowski, the Francis Crick Professor of Computational Neurobiology at the Salk Institute, says the book “gives a sense of the excitement on the cutting edge of neuroscience.” Sejnowski points out that connectomics, just like genomics, will be aided by the rapid advance of technology. “Once a certain threshold has been achieved, something that seemed impossible becomes possible, and soon becomes routine,” he writes.

Miswired brains

While everyone’s connectomes are different, extreme differences may account for mental disorders such as autism and schizophrenia. Neuroscientists have long speculated that autism and schizophrenia are caused by problems in brain wiring, but haven’t been able to test that theory. Once a typical human connectome has been mapped, scientists will be able to compare it to the wiring diagrams of small chunks of the brains of mice engineered to express autism or schizophrenia symptoms, in the hopes of figuring out why those disorders arise and, potentially, how to treat them.

“Finding those differences, of course, is not a cure or treatment, it’s just a starting point. But I would argue that being able to see those differences would be a huge step forward,” Seung says. “Imagine studying infectious diseases before there were microscopes. You could see the symptoms, but you couldn’t see the microbes. That’s why, for a long time, people didn’t believe schizophrenia had a biological basis, because they looked at the brain and there was nothing obviously wrong.”

In the last section of Connectome, Seung addresses some futuristic applications of connectomics, drawn directly from science fiction — ideas such as uploading human brains into computers or freezing bodies to preserve them until technology is developed to bring them back to life.

“My goal in those chapters is to point out that we can start to examine those dreams in a critical way,” Seung says. For example, he suggests that cryogenics is only a feasible plan if it can be shown that the connectome survives the freezing and thawing intact. “My point in those chapters is to introduce a dose of science into science fiction.”
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http://feedproxy.google.com/%7Er/SharpBrains/%7E3/rk8UKC9rolI/ To Be (Your Connectome), or Not to Be (Your Genome) http://feedproxy.google.com/%7Er/SharpBrains/%7E3/rk8UKC9rolI/ http://www.sciencedaily.com/releases/2012/02/120206143948.htm It's not solitaire: Brain activity differs when one plays against others http://www.sciencedaily.com/releases/2012/02/120206143948.htm http://feedproxy.google.com/%7Er/SharpBrains/%7E3/bGHOi2d8NZg/ Brain Awareness Week is Approaching: March 12-18th, 2012 http://feedproxy.google.com/%7Er/SharpBrains/%7E3/bGHOi2d8NZg/ http://brainblogger.com/2012/02/06/a-nicotine-patch-a-day-keeps-the-cognitive-impairment-away/ A Nicotine Patch a Day Keeps the Cognitive Impairment Away http://brainblogger.com/2012/02/06/a-nicotine-patch-a-day-keeps-the-cognitive-impairment-away/ http://www.psychologytoday.com/collections/201202/noise-noise-noise Noise, Noise, Noise! http://www.psychologytoday.com/collections/201202/noise-noise-noise
How to turn down the volume in an increasingly loud world—and why you should.
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http://www.psychologytoday.com/collections/201202/brand-me Brand: Me http://www.psychologytoday.com/collections/201202/brand-me
Are you a Mac or a PC? And just what does that say about you?
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http://mindhacks.com/2012/02/04/gocognitive-2-0/ goCognitive 2.0 http://mindhacks.com/2012/02/04/gocognitive-2-0/ ]]> http://mindhacks.com/2012/02/04/dressing-psychologists-as-wizards-in-court/ Dressing psychologists as wizards in court http://mindhacks.com/2012/02/04/dressing-psychologists-as-wizards-in-court/ ]]> http://brainblogger.com/2012/02/03/the-many-emerging-roles-of-astrocytes/ The Many Emerging Roles of Astrocytes http://brainblogger.com/2012/02/03/the-many-emerging-roles-of-astrocytes/ http://web.mit.edu/newsoffice/2012/dicarlo-bcs-head-0202.html James DiCarlo to head Department of Brain and Cognitive Sciences http://web.mit.edu/newsoffice/2012/dicarlo-bcs-head-0202.html
DiCarlo succeeds Mriganka Sur, who will leave his position as department head to become the director of the Simons Center for the Social Brain at MIT, a new initiative that aims to catalyze innovative research on the social brain and translate that work into the improved diagnosis and treatment of autism spectrum disorders.

“Mriganka Sur has led BCS through a period of spectacular growth,” says Marc Kastner, dean of the School of Science. “He developed strong working relationships with the new McGovern Institute for Brain Research and the new Picower Institute for Learning and Memory. He has hired a distinguished and diverse faculty, which has led the department into the very top rank in neuroscience and cognitive science, and consolidated the department in its new home in Building 46. It has been an honor and pleasure for me to work with him as a fellow department head and as dean, and I look forward to our continued collaboration in his role as director of the Simons Center for the Social Brain.”

DiCarlo’s research aims to discover how a complex network of brain regions enables rapid and effortless visual recognition of objects, and to translate that new knowledge into computational models of the brain. The ultimate goal of his research is to build a systematic, quantitative understanding of the neuronal computations that underlie the brain’s remarkable capacity for object recognition. This understanding will underlie new machine vision systems, will provide a basis for neural prosthetics to restore or augment lost senses, and might ultimately support an understanding of how perceptual processing is altered in human conditions such as agnosia, dyslexia and autism. 

“Jim DiCarlo is an accomplished systems neuroscientist who has a deep appreciation of all aspects of research in the department — cognitive science, computational, systems, cellular and molecular neuroscience,” Kastner says. “He is deeply committed to the educational programs of the department and enhancing its cohesiveness as a community. I am committed to helping him reach his goals in these areas while maintaining the great intellectual strength of BCS.”

DiCarlo earned his BS from Northwestern University with highest distinction in biomedical engineering in 1990, and his PhD and MD in 1998 from Johns Hopkins University. Upon completion of his doctoral degrees, he spent a year as a postdoc at the Krieger Mind/Brain Institute at Johns Hopkins and continued his research at the Howard Hughes Medical Institute and Division of Neuroscience at the Baylor College of Medicine.

Since joining MIT in 2002, DiCarlo has received several awards for his research, such as the McKnight Scholar Award in Neuroscience, the Pew Scholar Award in Biomedical Sciences, the Surdna Research Foundation Award, and the Sloan Research Fellowship. He has also won the MIT School of Science Prize for Excellence in Undergraduate Teaching.]]>
http://feeds.b5media.com/%7Er/b5media/MentalHealthNotes/%7E3/LnjNhrHtXnU/ Angry Moms Who Want Ellen DeGeneres Fired Are Bad For Our Mental Health http://feeds.b5media.com/%7Er/b5media/MentalHealthNotes/%7E3/LnjNhrHtXnU/ Schweddy Balls" ice cream from store shelves because it was considered sooo offensive to their little darlings? Well, they're at it again. This time though, they want our beloved Ellen DeGeneres fired from being the spokesperson for JC Penney because she's "openly gay". If you ask me, these moms and their open negativity and hatred are just bad for our mental health. More »

Post from: Blisstree

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http://www.sciencedaily.com/releases/2012/02/120202092259.htm Young children exposed to anesthesia multiple times show elevated rates of ADHD http://www.sciencedaily.com/releases/2012/02/120202092259.htm http://www.sciencedaily.com/releases/2012/02/120201120930.htm Blood test accurately distinguishes depressed patients from healthy controls http://www.sciencedaily.com/releases/2012/02/120201120930.htm http://westallen.typepad.com/brains_on_purpose/2012/02/excellent-example-of-why-people-dont-listen.html Wah, wah, wah: Excellent example of why people don't listen, even if you have good information http://westallen.typepad.com/brains_on_purpose/2012/02/excellent-example-of-why-people-dont-listen.html http://www.medicalnewstoday.com/releases/240994.php Access To Psychotropic Medicines Affected By Health Systems Factors http://www.medicalnewstoday.com/releases/240994.php http://www.medicalnewstoday.com/releases/240976.php National Study Shows Majority Of Self-Harming Adolescents Don't Receive A Mental Health Assessment During Emergency Room Visit http://www.medicalnewstoday.com/releases/240976.php http://www.medicalnewstoday.com/releases/240968.php A Glass Of Milk A Day Could Benefit Your Brain http://www.medicalnewstoday.com/releases/240968.php http://web.mit.edu/newsoffice/2012/mit-davos-talks-0131.html MIT faculty speak at the World Economic Forum in Davos http://web.mit.edu/newsoffice/2012/mit-davos-talks-0131.html
The five-day meeting, which brings together leaders in business, politics, academia and other areas, hosted a variety of discussions revolving around this year’s theme: “The Great Transformation: Shaping New Models.”

A troubled global economy with high unemployment dominated many of the meeting’s conversations. In a panel on the future of economics, economists including Peter Diamond, Institute Professor Emeritus and a winner of last year’s Nobel Prize in Economics, and MIT graduates Bob Shiller and Joe Stiglitz agreed that many economic models failed to recognize the nature of the current economic crisis because they largely ignored the effects of contagion and connectedness — unable to factor in the financial connections between institutions and the global risk of bankruptcy cascades. Panelists said more attention to models recognizing the role of collateral and new models, such as those incorporating behavioral economics, may offer a more accurate outlook.

MIT researchers also said that basic research in neuroscience will play a significant role in shaping societies, behavior and economic progress. MIT President Susan Hockfield spoke at Davos of the importance of basic brain research in fields other than neuroscience.

“New findings from neuroscience will have profound implications in fields far beyond the brain and mind, and well beyond psychology or medicine,” Hockfield said.

An analysis of how human nature could improve society was the topic of discussion among faculty members H. Robert Horvitz, the David H. Koch Professor of Biology and a Nobel laureate; Nancy Kanwisher, the Walter A. Rosenblith Professor of Cognitive Neuroscience; Alex “Sandy” Pentland, the Toshiba Professor of Media Arts and Sciences; and Tomaso Poggio, the Eugene McDermott Professor in the Brain Sciences and Human Behavior. One example is what the group termed “trust networks”: communities, such as open-source software users, that combine technical know-how with a certain amount of trust. Code creators, sharers and users need to trust each other in order to build on and propagate a software program. The researchers argued that understanding how trust plays into such large-scale networks may foster more successful innovations for society.

The researchers also discussed new advances in brain imaging, exploring the ever-closing gap between artificial and human intelligence. In the near future, they said, neuroscientists may be able to construct a precise model of the human brain, which could serve as a testing ground for potential therapies as well as a blueprint for artificially intelligent machines.

Yossi Sheffi, the Elisha Gray II Professor of Engineering Systems, moderated a panel on vulnerabilities in the global supply chain. Piracy, the effects of climate change, and weaknesses in cybersecurity are significant risks to the global trade of goods and services; panelists suggested that governments work together to reduce the impact of such risks.

Other MIT researchers who participated in Davos this year included Ed Boyden, the Benesse Career Development Associate Professor of Research in Education; Neil Gershenfeld, Director of the MIT Center for Bits and Atoms; Carlo Ratti, Associate Professor of the Practice in the Department of Urban Studies and Planning and Director of the SENSEable City Laboratory; Adèle Naudé Santos, Dean of the MIT School of Architecture and Planning; and Tim Berners-Lee, 3Com Founders Professor of Engineering and director of the World Wide Web Consortium (W3C).

Ed Boyden participated in a panel on leadership, in which panelists looked at the complex pressures that leaders face, including rapidly changing environments, technology, and social crises. Carlo Ratti presented a project for a new, interactive urban design in Mexico, called Ciudad Creativa Digital, with Mexican president Felipe Calderon. Adèle Naudé Santos and Neil Gershenfeld contributed to a broad discussion on innovations in social and technological models. Gershenfeld noted that smart materials and the digital revolution have made it possible for ordinary people to create new technologies, while Santos argued that the physical environment — particularly modern cities — is essential to making connections between people.

Susan Hockfield and MIT hosted three private events: a breakfast discussion about neuroscience moderated by Nature Editor in Chief Philip Campbell and featuring Bob Horvitz, Nancy Kanwisher and Tomaso Poggio; a dinner discussion about the fate of the Eurozone featuring Peter Diamond and Nouriel Roubini, a Professor of Economics and International Business at New York University’s Stern School made famous for having predicted the housing crisis; and a reception for friends of MIT.

Hockfield, who serves as a Director of the WEF, said, “The large number of MIT faculty in attendance covered a lot of academic ground, but one message they all sent to Forum attendees was this: solving the toughest problems in the world requires science, mathematics and engineering. It’s an important message in any era and particularly important in times of fiscal austerity.”
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http://westallen.typepad.com/brains_on_purpose/2012/01/are-character-and-personality-overrated.html Are character and personality overrated? Yes, says author of new book SITUATIONS MATTER http://westallen.typepad.com/brains_on_purpose/2012/01/are-character-and-personality-overrated.html http://feeds.b5media.com/%7Er/b5media/MentalHealthNotes/%7E3/bxdEaWV_o60/ Ketamine Nation? Special K Works Better Than Prozac At Treating Depression http://feeds.b5media.com/%7Er/b5media/MentalHealthNotes/%7E3/bxdEaWV_o60/ could be useful in treating depression. This week? Beat the blues with ketamine! The drug—also known as 'Special K'—can lift even suicidal depression in just a few hours, researchers say. More »

Post from: Blisstree

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http://brainblogger.com/2012/01/31/diabetes-impairs-cognition/ Diabetes Impairs Cognition http://brainblogger.com/2012/01/31/diabetes-impairs-cognition/ http://westallen.typepad.com/brains_on_purpose/2012/01/lecture-on-metaphor-and-embodied-cognition.html Lecture on metaphor and embodied cognition http://westallen.typepad.com/brains_on_purpose/2012/01/lecture-on-metaphor-and-embodied-cognition.html http://brainblogger.com/2012/01/27/media-violence-leads-to-real-violence/ Media Violence Leads to Real Violence http://brainblogger.com/2012/01/27/media-violence-leads-to-real-violence/ http://brainposts.blogspot.com/2012/01/epidemiology-of-brain-cancer.html Epidemiology of Brain Cancer http://brainposts.blogspot.com/2012/01/epidemiology-of-brain-cancer.html A recent summary of the trends in cancer highlighted the epidemiology of brain and other nervous system tumors.  In the United States, 213,500 brain and other nervous system tumors were diagnosed during the four year period from 2004 through 2007.

Brain and other nervous systems (ONS) tumors rank fourteenth in the top 15 cancers for men and fifteenth in the top 15 cancers for women in the United States.

Overall rates for brain and ONS tumors during this period were 22.37 per 100,000 for men and slightly higher at 26.55 per 100,000 for women.

In adults, the majority (66.3%) of brain and ONS tumors were benign.  Although brain and ONS tumors are less common in children, when they occur they are less likely (34.8%) to be benign.

The most common histological types of brain and ONS tumors in the most recent analysis were (rate per 100,000):

  1. Meningioma (9.2)
  2. Glioblastoma (4.4)
  3. Tumors of the sella turcica region (3.6)
  4. Acoustic neuroma (1.5)
  5. Astrocytomas (1.2)

Glioblastomas and astrocytomas are malignant brain cancers while the other three types of tumors are overwhelmingly benign with less than 3% classified as malignant.

Five year survival rates for the malignant brain cancers have improved over the last approximately twenty year periods.  Here are the most recent five year survival rates group by age:

  • 19 and younger (75.3%)
  • 20-39 (65.1%)
  • 40-64 years (26.6%)
  • 65 and older (<5%)

The five year survival rates demonstrate a significant trend for a poorer prognosis with older age groups.  This represents a trend for brain cancer in older populations to be of a more aggressive type with poorer response to surgery, radiation and chemotherapy interventions.

The rates of brain cancer are relatively similar throughout the geographic regions of the United States and throughout the world.  This supports a predominant genetic role for brain cancer risk.  Known risk factors for brain cancer are:

  • Family history of brain cancer
  • Caucasian race
  • Advanced age
  • Exposure to ionizing radiation
  • Exposure to toxic chemicals

Several studies have demonstrated that individuals with atopic diseases such as eczema, seasonal allergies and asthma have a reduced risk of malignant gliomas.  The mechanism for this protective effect is unclear.

In the next two posts, I will summarize some of the recent research related to cell phone use and brain cancer rates.  Additionally, I will review an interesting study suggesting the antiseizure drug valproic acid may contribute to increased survival duration in brain cancer.

Photo of bird known as the plain chachalaca from the author's files.


Kohler, B., Ward, E., McCarthy, B., Schymura, M., Ries, L., Eheman, C., Jemal, A., Anderson, R., Ajani, U., & Edwards, B. (2011). Annual Report to the Nation on the Status of Cancer, 1975-2007, Featuring Tumors of the Brain and Other Nervous System JNCI Journal of the National Cancer Institute, 103 (9), 714-736 DOI: 10.1093/jnci/djr077
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http://web.mit.edu/newsoffice/2012/empathy-conflict-0123.html Seeking the neurological roots of conflict http://web.mit.edu/newsoffice/2012/empathy-conflict-0123.html
Those chance experiences got Bruneau, who taught high school science for several years, interested in the psychology of human conflict. While teaching, he also volunteered as counselor for a conflict-resolution camp in Ireland that brought Catholic and Protestant children together. At MIT, Bruneau is now working with associate professor of cognitive neuroscience Rebecca Saxe to figure out why empathy — the ability to feel compassion for another person’s suffering — often fails between members of opposing conflict groups.

“What are the psychological barriers that are put up between us in these contexts of intergroup conflict, and then, critically, what can we do to get past them?” Bruneau asks.

Bruneau and Saxe are also trying to locate patterns of brain activity that correlate with empathy, in hopes of eventually using such measures to determine how well people respond to reconciliation programs aimed at boosting empathy between groups in conflict.

“We’re interested in how people think about their enemies, and whether there are brain measures that are reliable readouts of that,” says Saxe, who is an associate member of MIT’s McGovern Institute for Brain Research. “This is a huge vision, of which we are at the very beginning.”

Before researchers can use tools such as magnetic resonance imaging (MRI) to evaluate whether conflict-resolution programs are having any effect, they need to identify brain regions that respond to other people’s emotional suffering. In a study published Dec. 1 in Neuropsychologia, Saxe and Bruneau scanned people’s brains as they read stories in which the protagonist experienced either physical or emotional pain. The brain regions that responded uniquely to emotional suffering overlapped with areas known to be involved in the ability to perceive what another person is thinking or feeling.

Failures of empathy


Hoping to see a correlation between empathy levels and amount of activity in those brain regions, the researchers then recruited Israelis and Arabs for a study in which subjects read stories about the suffering of members of their own groups or that of conflict-group members. The study participants also read stories about a distant, neutral group — South Americans.

As expected, Israelis and Arabs reported feeling much more compassion in response to the suffering of their own group members than that of members of the conflict group. However, the brain scans revealed something surprising: Brain activity in the areas that respond to emotional pain was identical when reading about suffering by one’s own group or the conflict group. Also, those activity levels were lower when Arabs or Israelis read about the suffering of South Americans, even though Arabs and Israelis expressed more compassion for South Americans’ suffering than for that of the conflict group.

Those findings, published Jan. 23 in Philosophical Transactions of the Royal Society: Biological Sciences, suggest that those brain regions are sensitive to the importance of the opposing group, not whether or not you like them.

Joan Chiao, an assistant professor of psychology at Northwestern University, says those brain regions may be acting as a “thermometer” for conflict. “It’s a really fascinating study because it’s the first to examine the neural basis of people’s behavior in longstanding conflicts, as opposed to groups that are distant and don’t have a long history of intergroup strife,” says Chiao, who was not involved in the research.

However, because the study did not reveal any correlation between the expression of empathy and the amount of brain activity, more study is needed before MRI can be used as a reliable measure of empathy levels, Saxe says.

“We thought there might be brain regions where the amount of activity was just a simple function of the amount of empathy that you experience,” Saxe says. “Since that’s not what we found, we don’t know what the amount of activity in these brain regions really means yet. This is basically a first baby step, and one of the things it tells us is that we don’t know enough about these brain regions to use them in the ways that we want to.”

Bruneau is now testing whether these brain regions send messages to different parts of the brain depending on whether the person is feeling empathy or not. He hypothesizes that when someone reads about the suffering of an in-group member, the brain regions identified in this study send information to areas that process unpleasant emotions, while stories about suffering of a conflict-group member activate an area called the ventral striatum, which has been implicated in schadenfreude — taking pleasure in the suffering of others.]]>
http://brainposts.blogspot.com/2012/01/parent-training-and-conduct-disorder.html Parent Training and Conduct Disorder Outcome http://brainposts.blogspot.com/2012/01/parent-training-and-conduct-disorder.html Three previous posts examined the clinical neuroscience disorder antisocial personality disorder (ASPD).  This condition results in high societal costs for crime and incarceration for individuals with ASPD.

ASPD appears to have significant genetic contributions and brain imaging studies show abnormal brain maturational patterns in the premotor cortex area as well as impaired processing of facial emotional expression.

Antisocial personality is an early age of onset disorder with conduct disorder symptoms emerging during childhood and adolescence.   Their is no evidence-based consensus on pharmacological treatment options in conduct disorder and ASPD.

This leaves psychological and behavioral interventions as the current primary treatment option.  But do these types of interventions work and do they produce lasting changes in the longitudinal trajectory of ASPD.

Drugli and colleagues from Norway published an outcome study of conduct disorder following a randomized controlled trial of a parental training intervention known as "The Incredible Years".

The Incredible Years parent training program emphasized developing parental skills to improve the child's social and behavioral development.  Key features include instruction on how to play with other children, social and emotional skills training, establishment of routines and rules to promote responsibility, strategies to manage misbehavior and teaching problem solving.  More information about The Incredible Years program can be found here.

Drugli and colleagues followed a subgroup of children in their initial randomized trial.  This follow up lasted five to six years.  Control children in the original study were on a wait list for six months and then received The Incredible Years intervention so no controlled group outcome can be made.  However,  in the follow up analysis the research team found only one third of children enrolled with an initial diagnosis of oppositional defiant disorder or conduct continued to meet diagnostic criteria for the disorder.

Predictors for persistence of a clinical diagnosis at outcome included:

  1. female gender
  2. living with mother only
  3. a baseline diagnosis of conduct disorder rather than oppositional defiant disorder
  4. higher levels of conduct disorder symptoms
  5. higher baseline levels of internalizing symptoms such as anxiety or depression
  6. maternal depressive symptoms after treatment intervention
  7. maternal stress rating of parenting
The predictor findings suggest that parental factors play a key role in the effectiveness of the parental training intervention.  Single mothers and those with higher stress and depression symptoms may have more trouble in continuing to use the skills learned with the intervention.

Additionally, this intervention may not be as effective for children with more severe conduct disorders.  

Parental training in childhood behavioral disorders provides a reasonable first step for early treatment of those at risk of antisocial personality.  However, such an intervention strategy is limited by frequent parental emotional and behavioral problems found in the families of high-risk children.

Increased research targeting the secondary prevention of aggressive behaviors and ASPD in children with conduct disorder should be a priority.

Photo of a flicker searching for food from the author's file.

Drugli MB, Larsson B, Fossum S, & Mørch WT (2010). Five- to six-year outcome and its prediction for children with ODD/CD treated with parent training. Journal of child psychology and psychiatry, and allied disciplines, 51 (5), 559-66 PMID: 20015193


 
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http://mindhacks.com/2012/01/21/a-treasure-hunt-for-the-mysteries-of-mind-and-brain/ A treasure hunt for the mysteries of mind and brain http://mindhacks.com/2012/01/21/a-treasure-hunt-for-the-mysteries-of-mind-and-brain/ ]]> http://mindhacks.com/2012/01/20/the-peak-experiences-of-abraham-maslow/ The peak experiences of Abraham Maslow http://mindhacks.com/2012/01/20/the-peak-experiences-of-abraham-maslow/ ]]> http://brainposts.blogspot.com/2012/01/brain-imaging-in-antisocial-personality_19.html Brain Imaging in Antisocial Personality: II http://brainposts.blogspot.com/2012/01/brain-imaging-in-antisocial-personality_19.html This is the second in a series of posts looking at recent imaging findings in antisocial personality.  In the first post, I reviewed an fMRI study that found deficits in connectivity maturation involving the premotor cortex in a sample of incarcerated juveniles.

In this post, I will review a study looking a emotional face processing.  Accurately assessing the emotions of others and adjusting ones own behavior is a key component to social development and appropriate social behavior.

Individuals with antisocial personality disorder commonly display childhood and adolescent forms of the disorder.  These child and adolescent behaviors often meet the criteria for conduct disorder.  About 75% of children with conduct disorder will go on to develop adult antisocial personality disorder.

Passamonti and colleagues from the University of Cambridge in England recently completed and published a study of emotional face processing in a series of male adolescents with conduct disorder and control adolescents without conduct disorder.

Conduct disorder adolescents were divided into those with an earlier age of onset (at least one significant conduct disorder symptoms prior to age 10) and those whose first significant symptom developed at 10 or later.  This classification is considered valid as adolescents with later emerging conduct disorder problems are felt to be more influenced by peer group behaviors.

Subjects completed a series of face emotion tasks while being imaged using functional magnetic resonance imaging.  Emotional images presented fell into one of three emotions--angry faces, sad faces or a neutral facial expression.

The key findings from the study related to amygdala responses were:

  • Both groups of adolescents with conduct disorder demonstrated a reduced responses in brain regions felt to be linked to antisocial behavior
  • Early onset conduct disorder adolescents showed reduced amygdala activation for sad versus neutral faces
  • Early onset conduct disorder adolescents showed reduced amygdala activation for sad faces relative to the control fixation task
The conduct disorder groups also demonstrated abnormal responses to facial emotions in ventromedial prefrontal cortex, orbitofrontal cortex and the insula. 

The authors note their study provides some support for the distinction between early and late onset conduct disorder.  Although these groups share some features in emotional processing, early onset conduct disorder appears to be associated with more severe deficits in accurately processing sad faces.

This study suggests emotional processing deficits may contribute to some of the behaviors of antisocial personality.  Such individuals are typically seen to lack empathy and to behave without regard for the effect of their behavior on others.  Part of this pattern may be a reduced ability to recognize emotional expression in others.  A part of their behavior may represent a partial "blindness" to sad emotional states of those around them including family members and peers.

The authors note their study my provide a impetus to describing a phenotype with a poor prognosis and likely continuation of antisocial behavior into adulthood.  Functional MRI studies of neural markers may aid in defining high-risk groups for more intensive secondary prevention intervention.

Photo of great blue heron at sunrise in South Padre Island, Texas from the author's files.


Passamonti L, Fairchild G, Goodyer IM, Hurford G, Hagan CC, Rowe JB, & Calder AJ (2010). Neural abnormalities in early-onset and adolescence-onset conduct disorder. Archives of general psychiatry, 67 (7), 729-38 PMID: 20603454

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http://feeds.newscientist.com/c/749/f/10918/s/1bf77e0b/l/0L0Snewscientist0N0Carticle0Cdn213710Edisrupted0Ebody0Eclock0Emay0Eprime0Eyou0Efor0Eschizophrenia0Bhtml0DDCMP0FOTC0Erss0Gnsref0Fmental0Ehealth/story01.htm Disrupted body clock may prime you for schizophrenia http://feeds.newscientist.com/c/749/f/10918/s/1bf77e0b/l/0L0Snewscientist0N0Carticle0Cdn213710Edisrupted0Ebody0Eclock0Emay0Eprime0Eyou0Efor0Eschizophrenia0Bhtml0DDCMP0FOTC0Erss0Gnsref0Fmental0Ehealth/story01.htm


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http://brainposts.blogspot.com/2012/01/brain-imaging-in-antisocial-personality.html Brain Imaging in Antisocial Personality: I http://brainposts.blogspot.com/2012/01/brain-imaging-in-antisocial-personality.html Antisocial personality disorder (ASPD) is linked to a variety of emotional and behavioral abnormalities with significant public health implications.

Key components of antisocial personality disorder include irritability with anger dysregulation.  Individuals with ASPD are quick tempered with anger outbursts commonly leading to physical or emotional aggressiveness towards others.

The emotional and behavioral abnormalities in ASPD may provide a model for studying specific brain regions controlling these functions.  In the next few posts, I will review some of the brain imaging abnormalities that have been linked to ASPD.  I will first begin by looking at a study of functional connectivity in juvenile offenders.

Shannon from Washington University in Saint Louis and colleagues from the Oregon Health and Science University and the University of New Mexico have published a study of the default network in a group of juvenile offenders.

The authors of this study note functional connectivity is a developmental process.  Children's brain show different functional connectivity patterns than that of adults--children have strong short-distant connections while adults have stronger long-distant connections.  They note that abnormal maturation patterns in functional connectivity have been linked to several clinical neuroscience disorders including ADHD, autism, schizophrenia, Alzheimer's disease and Parkinson's disease.  These finding support the potential for abnormal maturation patterns in conduct disorder and antisocial personality disorder.

The key elements in the design of their study were:
Subjects: 122 juveniles incarcerated for a variety of crimes including physical and sexual assault contrasted with 95 control individuals
Scanning method: Mobile fMRI 1.5T scanner (cases) and 3.0T scanner (controls)
Scanning analysis: Resting state connectivity among brain systems
Psychometric assessment: Hare Psychopathy Checklist (PCL-YV) consisting of a empathy subfactor and an impulsivity/need for stimulation factor

No resting connectivity abnormalities were linked to the empathy factor from the PCL-YV.  However, some interesting findings were noted in the impulsivity domain.   The found differences linked to impulsivity in the motor planning region of the cortex (premotor cortex).

High impulsivity scores common in the juvenile offender group was associated with connections between the motor planning region and regions linked to spontaneous behavior and self-referential cogniton.

In contrast, low impulsivity offenders and controls showed associations between this motor planning region with spatial attention and executive function and control.

Interestingly, the high impulsivity pattern of connectivity appeared common in the youngest controls.  Older controls showed the typical motor planning-executive functioning connectivity.

The authors propose that "impulsivity in the offender population is a consequence of delay in typical development rather than a distinct abnormality".

The authors note that their finding raises the possibility that specific intervention strategies to modify functional maturation connectivity may promising.  The relatively focal nature of deficits in this study support the potential for specific therapeutic remediation.

This finding in juvenile populations needs to be replicated in adult offender populations.  Impulsivity and aggressiveness abnormalities in ASPD have an early age of onset and is persistent into adulthood for many individuals.

Nevertheless, designing specific impulsivity remediation treatments with serial functional connectivity maturation analysis holds promise for new secondary prevention strategies in ASPD.

Filtered image of a pair of laughing gulls from the author's file.  Original photo can be found here.

Shannon BJ, Raichle ME, Snyder AZ, Fair DA, Mills KL, Zhang D, Bache K, Calhoun VD, Nigg JT, Nagel BJ, Stevens AA, & Kiehl KA (2011). Premotor functional connectivity predicts impulsivity in juvenile offenders. Proceedings of the National Academy of Sciences of the United States of America, 108 (27), 11241-5 PMID: 2170923621709236
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http://brainposts.blogspot.com/2012/01/twin-study-of-antisocial-personality.html Twin Study of Antisocial Personality Disorder http://brainposts.blogspot.com/2012/01/twin-study-of-antisocial-personality.html Twin studies provide a valuable method to explore the genetic and environmental contributions to a variety of clinical neuroscience disorders.

Twin studies use a method where identical twins (monozygotic) sharing 100% of their genes are compared to non-identical twins (dizygotic) who share 50% of their genes.

Disorders that are entirely environmental would be found at the same rates in non-identical twins and indentical twins.  Disorders with a strong genetic contribution would be more likely to be found in monozygotic twin (where one twin is affected) than in a dizygotic twin (where one twin is affected).

Antisocial personality disorder (ASPD) is an early-onset disorder characterized by aggressive behavior, frequent rule breaking and failure to consider the effect of one's behavior on other individuals.  It represents one of the most valid of the personality disorder diagnoses as many defining characteristics are behavioral in nature.  More common in men than in women, this condition contributes significantly to the burden of violent and non-violent crime, substance abuse and prison crowding.

Kendler and colleagues recently published a twin study of the DSM-IV criteria for ASPD in a cohort of twins from the Virginia Adult Psychiatric and Substance Use Disorders.  Data from 4291 twins were used in the analysis and included a factor analysis of the ASPD phenotype followed by twin analysis.

The research group found two distinct ASPD phenotypes in the factor analysis with specific ASPD criteria loading on each factor:
Factor 1: nonconformance, irritability/aggression and reckless disregard for others
Factor 2: deceitfulness, impulsivity/failure to plan, irresponsibility and lack of remorse for behavior

The subsequent twin analysis confirmed two genetic factors in adult ASPD with a confirmation of the factor analysis criteria loading.   Heritability (an estimate of genetic contribution) for individual ASPD criteria varied from .12 to .57.

Additional support for these two factors came from a study of discriminant validity--the ability of the genetic factors to describe a unique clinical presentation.  The clinical features found in each of the two factors were:
Factor 1: presence of childhood conduct disorder, early age at first alcoholic drink, high number of maximum drinks consumed in 24 hours, treatment seeking for alcohol dependence and lower educational level
Factor 2: novelty seeking personality and history of major depression

The authors note their study supports a view of two types of adult antisocial phenotypes.  Factor one matches the general description of the psychopath with many traits persistent throughout adult life.  Factor two matches primarily a deficit of disinhibition the may "reflect disturbances in anterior brain systems mediating affective and behavioral control".

This is an important study the supports more vigorous phenotypic description of adults with antisocial personality.  These subtype descriptions may play a key role in understanding cognitive, structural and functional imaging studies in adult ASPD.

In the next few posts, I will review some of the emerging imaging research related to ASPD.

Photo of olive sparrow from the author's file.

Kendler KS, Aggen SH, & Patrick CJ (2012). A Multivariate Twin Study of the DSM-IV Criteria for Antisocial Personality Disorder. Biological psychiatry, 71 (3), 247-53 PMID: 21762879
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http://mindhacks.com/2012/01/17/gimme-shelter/ Gimme Shelter http://mindhacks.com/2012/01/17/gimme-shelter/ ]]> http://feeds.newscientist.com/c/749/f/10918/s/1b209cd1/l/0L0Snewscientist0N0Carticle0Cmg212284420B40A0A0Ehijack0Eyour0Eown0Edreams0Eto0Eimprove0Eyour0Eskills0Bhtml0DDCMP0FOTC0Erss0Gnsref0Fmental0Ehealth/story01.htm Hijack your own dreams to improve your skills http://feeds.newscientist.com/c/749/f/10918/s/1b209cd1/l/0L0Snewscientist0N0Carticle0Cmg212284420B40A0A0Ehijack0Eyour0Eown0Edreams0Eto0Eimprove0Eyour0Eskills0Bhtml0DDCMP0FOTC0Erss0Gnsref0Fmental0Ehealth/story01.htm Inception, in real life: lucid dreams offer people the ability to control their dreams and improve not only skills, but also mental health


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http://feedproxy.google.com/%7Er/scienceblogs/YsBw/%7E3/mYssR-C3zQ0/neurophilosophy_now_hosted_by_the_guardian.php Neurophilosophy now hosted by The Guardian http://feedproxy.google.com/%7Er/scienceblogs/YsBw/%7E3/mYssR-C3zQ0/neurophilosophy_now_hosted_by_the_guardian.php neurophilosophy_620_v2.jpg

AFTER four years here at ScienceBlogs.com, Neurophilosophy is moving to a new home. As of today, it will be hosted by The Guardian.

During its time here, the blog has grown from strength to strength. It has received over 2.5 million page views, was featured regularly on the New York Times science page, and has been translated into about a dozen languages. It has also enabled me to earn a living as a freelance science writer for the past two years.

Thanks to everyone here at ScienceBlogs and especially to all my readers. I hope you'll continue reading. The URL for the new blog is: http://www.guardian.co.uk/science/neurophilosophy and the feed is here: http://www.guardian.co.uk/science/neurophilosophy/rss; and here's my first post, 'The illlusion of attention.'

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http://feedproxy.google.com/%7Er/scienceblogs/YsBw/%7E3/clerfaLkxYc/human_echolocation_activates_visual_parts_of_the_brain.php Human echolocation activates visual parts of the brain http://feedproxy.google.com/%7Er/scienceblogs/YsBw/%7E3/clerfaLkxYc/human_echolocation_activates_visual_parts_of_the_brain.php WE all know that bats and dolphins use echolocation to navigate, by producing high frequency bursts of clicks and interpreting the sound waves that bounce off objects in their surroundings. Less well known is that humans can also learn to echolocate. With enough training, people can use this ability to do extraordinary things. Teenager Ben Underwood, who died of cancer in 2009, was one of a small number of blind people to master it. As the clip below shows, he could use echolocation not only to navigate and avoid obstacles, but also to identify objects, rollerskate and even play video games. 

Very little research has been done on human echolocation, and nothing is known about the underlying brain mechanisms. In the first study of its kind, Canadian researchers used functional magnetic resonance imaging (fMRI) to monitor the brain activity of two blind echolocation experts. Their findings, published today in the open access journal PLoS ONE, show that echolocation engages regions of the brain that normally process vision.  

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http://feedproxy.google.com/%7Er/scienceblogs/YsBw/%7E3/gTyQqiSVd0s/a_whiff_of_early_brain_evolution.php A whiff of early brain evolution http://feedproxy.google.com/%7Er/scienceblogs/YsBw/%7E3/gTyQqiSVd0s/a_whiff_of_early_brain_evolution.php rowe6HR.jpg
Skull of Hadrocodium wui. (Image courtesy of Mark Klinger and Zhe-Xi Luo, Carnegie Museum of Natural History)

THE question of how mammals evolved their exceptionally large brains has intrigued researchers for years, and although many ideas have been put forward, none has provided a clear answer. Now a team of palaeontologists suggests that the mammalian brain evolved in three distinct stages, the first of which was driven by an improvement in the sense of smell. Their evidence, published in tomorrow's issue of Science, comes from two fossilized skulls, each measuring little more than 1cm in length. 

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http://feedproxy.google.com/%7Er/scienceblogs/YsBw/%7E3/JUMp0khQg0o/sleepy_brain_waves_predict_dream_recall.php Sleepy brain waves predict dream recall http://feedproxy.google.com/%7Er/scienceblogs/YsBw/%7E3/JUMp0khQg0o/sleepy_brain_waves_predict_dream_recall.php THE patterns of brain waves that occur during sleep can predict the likelihood that dreams will be successfully recalled upon waking up, according to a new study published in the Journal of Neuroscience. The research provides the first evidence of a 'signature' pattern of brain activity  associated with dream recall. It also provides further insight into the brain mechanisms underlying dreaming, and into the relationship between our dreams and our memories.

Cristina Marzano of the Sleep Psychophysiology Laboratory at the University of Rome and her colleagues recruited 65 students, selected on the basis of their sleeping habits. All of them had a regular sleep 'routine', going to bed at around the same time, and sleeping for an average of seven-and-a-half hours, every night. For the study, the participants slept for two consecutive nights in a sound-proof, temperature-controlled room in the lab. They were left to sleep uninterrupted on the first night, so that they would get accustomed to the new surroundings. 

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http://feedproxy.google.com/%7Er/scienceblogs/YsBw/%7E3/HBjmNaj1pcI/us_military_spy_crows_binladen.php US military planned using spy crows to find Osama bin Laden http://feedproxy.google.com/%7Er/scienceblogs/YsBw/%7E3/HBjmNaj1pcI/us_military_spy_crows_binladen.php

THE United States military funded research into using networks of 'spy crows' to locate soldiers who are missing in action, and extended the work to see if the birds might be useful in helping them to find Osama bin Laden. The idea may seem far-fetched, but unlike some military research programs (such as the Stargate remote-viewing program) it is actually based on sound science.

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http://feedproxy.google.com/%7Er/scienceblogs/wDAM/%7E3/MMZ9fTWGgGM/goodbye_scienceblogs.php Goodbye Scienceblogs http://feedproxy.google.com/%7Er/scienceblogs/wDAM/%7E3/MMZ9fTWGgGM/goodbye_scienceblogs.php NOTE: This blog has moved. The Frontal Cortex is now over here.

I've got some exciting news: Starting today, the Frontal Cortex will be moving over to the Wired website. Needless to say, the move comes with the usual mixture of emotions, as I've greatly enjoyed my four years as part of the Scienceblogs community. It's been an honor to share this space with such a fine collection of scientists and writers. I'm sad to be leaving. (I should note, by the way, that this move was planned long before Pepsi, etc.) However, I'm really thrilled to be joining the blog network of the publication that I contribute to in print. I apologize for the hassle of changing RSS feeds, bookmarks and all the rest, but I really hope we can make this move together. Regardless, thanks so much for reading!

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http://feedproxy.google.com/%7Er/scienceblogs/wDAM/%7E3/khtf5MwN6Ps/twitter_strangers.php Twitter Strangers http://feedproxy.google.com/%7Er/scienceblogs/wDAM/%7E3/khtf5MwN6Ps/twitter_strangers.php Over at Gizmodo, Joel Johnson makes a convincing argument for adding random strangers to your twitter feed:

I realized most of my Twitter friends are like me: white dorks. So I picked out my new friend and started to pay attention.

She's a Christian, but isn't afraid of sex. She seems to have some problems trusting men, but she's not afraid of them, either. She's very proud of her fiscal responsibility. She looks lovely in her faux modeling shots, although I am surprised how much her style aligns with what I consider mall fashion when she's a grown woman in her twenties. Her home is Detroit and she's finding the process of buying a new car totally frustrating. She spends an embarrassing amount of time tweeting responses to the Kardashian family.

One of the best things about Twitter is that, once you've populated it with friends genuine or aspirational, it feels like a slow-burn house party you can pop into whenever you like. Yet even though adding random people on Twitter is just a one-click action, most of us prune our follow list very judiciously to prevent tedious or random tweets to pollute our streams. Understandable! But don't discount the joy of discovery that can come by weaving a stranger's life into your own.

I'd argue that the benefits of these twitter strangers extend beyond the fleeting pleasures of electronic eavesdropping. Instead, being exposed to a constant stream of unexpected tweets - even when the tweets seem wrong, or nonsensical, or just plain silly - can actually expand our creative potential.

The explanation returns us to the banal predictability of the human imagination. In study after study, when people free-associate, they turn out to not be very free. For instance, if I ask you to free-associate on the word "blue," chances are your first answer will be "sky". Your next answer will probably be "ocean," followed by "green" and, if you're feeling creative, a noun like "jeans". The reason for this is simple: Our associations are shaped by language, and language is full of cliches.

How do we escape these cliches? Charlan Nemeth, a psychologist at UC-Berkeley, has found a simple fix. Her experiment went like this: A lab assistant surreptitiously sat in on a group of subjects being shown a variety of color slides. The subjects were asked to identify each of the colors. Most of the slides were obvious, and the group quickly settled into a tedious routine. However, Nemeth instructed her lab assistant to occasionally shout out the wrong answer, so that a red slide would trigger a response of "yellow," or a blue slide would lead to a reply of "green". After a few minutes, the group was then asked to free-associate on these same colors. The results were impressive: Groups in the "dissent condition" - these were the people exposed to inaccurate descriptions - came up with much more original associations. Instead of saying that "blue" reminded them of "sky," or that "green" made them think of "grass," they were able to expand their loom of associations, so that "blue" might trigger thoughts of "Miles Davis" and "smurfs" and "pie". The obvious answer had stopped being their only answer. More recently, Nemeth has found that a similar strategy can also lead to improved problem solving on a variety of creative tasks, such as free-associating on ways to improve traffic in the Bay Area.

The power of such "dissent" is really about the power of surprise. After hearing someone shout out an errant answer - this is the shock of hearing blue called "green" - we start to reconsider the meaning of the color. We try to understand this strange reply, which leads us to think about the problem from a new perspective. And so our comfortable associations - the easy association of blue and sky - gets left behind. Our imagination has been stretched by an encounter that we didn't expect.

And this is why we should all follow strangers on Twitter. We naturally lead manicured lives, so that our favorite blogs and writers and friends all look and think and sound a lot like us. (While waiting in line for my cappuccino this weekend, I was ready to punch myself in the face, as I realized that everyone in line was wearing the exact same uniform: artfully frayed jeans, quirky printed t-shirts, flannel shirts, messy hair, etc. And we were all staring at the same gadget, and probably reading the same damn website. In other words, our pose of idiosyncratic uniqueness was a big charade. Self-loathing alert!) While this strategy might make life a bit more comfortable - strangers can say such strange things - it also means that our cliches of free-association get reinforced. We start thinking in ever more constricted ways.

And this is why following someone unexpected on Twitter can be a small step towards a more open mind. Because not everybody reacts to the same thing in the same way. Sometimes, it takes a confederate in an experiment to remind us of that. And sometimes, all it takes is a stranger on the internet, exposing us to a new way of thinking about God, Detroit and the Kardashians.

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http://feedproxy.google.com/%7Er/scienceblogs/wDAM/%7E3/qJpMXmpPNyw/stress.php Stress http://feedproxy.google.com/%7Er/scienceblogs/wDAM/%7E3/qJpMXmpPNyw/stress.php I've got a new article in the latest Wired on the science of stress, as seen through the prism of Robert Sapolsky. The article isn't online yet (read it on the iPad!), but here are the opening paragraphs:

Baboons are nasty, brutish and short. They have a long muzzle and sharp fangs designed to inflict deadly injury. Their bodies are covered in thick, olive-colored fur, except on their buttocks, which are hairless. The species is defined by its social habits: The primates live in troops, or small groupings of several dozen individuals. These troops have a strict hierarchy, and each animal is assigned a specific ranking. While female rank is hereditary--a daughter inherits her mother's status--males compete for dominance. These fights can be bloody, but the stakes are immense: A higher rank means more sex. The losers, in contrast, face a bleak array of options: submission, exile, or death.

In 1978, Robert Sapolsky was a recent college graduate with a biology degree and ajobinKenya.Hehadsetoffforayearof fieldwork by himself among baboons before he returned to the US for grad school and the drudgery of the lab. At the time, Sapol- sky's wilderness experience consisted of short backpacking trips in the Catskill Moun- tains; he had lit a campfire exactly once. Most of what he knew about African wildlife he'd learned from stuffed specimens at the Museum of Natural History. And yet here he was in Nairobi, speaking the wrong kind of Swahili and getting ripped off by everyone he met. Eventually he made his way to the bush, a sprawling savanna filled with zebras and wildebeests and marauding elephants. "I couldn't believe my eyes," Sapolsky remem- bers. "There was an animal behind every tree. I was inside the diorama."

Sapolsky slowly introduced himself to a troop of baboons, letting them adjust to his presence. After a few weeks, he began recog- nizing individual animals, giving them nick- names from the Old Testament. It was a way of rebelling against his childhood Hebrew school teachers, who rejected the blasphemy of Darwinian evolution. "I couldn't wait for the day that I could record in my notebook that Nebuchanezzar and Naomi were off screwing in the bushes," Sapolsky wrote in A Primate's Memoir. "It felt like a pleas- ing revenge."

Before long, Sapolsky's romantic vision of fieldwork collided with the dismal reality of living in the African bush. His feet itched from a fungal infection, his skin was cov- ered in bug bites, the Masai stole his stuff, he had terrible diarrhea, and he was des- perately lonely. Sapolsky's subjects gave him no glimpse of good fellowship. They seemed to devote all of their leisure time--and baboon life is mostly leisure time--to mischief and malevolence. "One of the first things I discovered was that I didn't like baboons very much," he says. "They're quite awful to one another, constantly scheming and backstabbing. They're like chimps but without the self-control."

While Sapolsky was disturbed by the behavior of the baboons--this was nature, red in tooth and claw--he realized that their cruelty presented an opportunity to investi- gate the biological effects of social upheaval. He began to notice, for instance, that the males at the bottom of the hierarchy were thinner and more skittish."They just didn't look very healthy," Sapolsky says. "That's when I began thinking about how damn stressful it must be to have no status. You never know when you're going to get beat up. You never get laid. You have to work a lot harder for food."

And so Sapolsky set out to test the hypothesis that the stress involved in being at the bottom of the baboon hierarchy led to health problems. At the time, stress was mostly ignored as a scientific subject. It was seen as an unpleasant mental state with few long- term consequences. "A couple of studies had linked stress to ulcers, but that was about it," he says. "It struck most doctors as extremely unlikely that your feelings could affect your health. Viruses, sure. Carcinogens, absolutely. But stress? No way." Sapolsky, how- ever, was determined to get some data. He wasn't yet thinking lofty thoughts about human beings or public health. His transformation into one of the leading researchers on the sci- ence of stress would come later. Instead, he was busy learning how to shoot baboons with anesthetic darts and then, while they were plunged into sleep, quickly measure the levels of stress hormones in their blood.

In the decades since, Sapolsky's speculation has become scientific fact. Chronic stress, it turns out, is an extremely dangerous condition. And it's not just baboons: People are just as vulnerable to its effects as those low-ranking male apes. While stress doesn't cause any single disease--ironically, the causal link between stress and ulcers has been largely disproved--it makes most diseases significantly worse. The list of ailments connected to stress is staggeringly diverse and includes everything from the common cold and lower-back pain to Alzheimer's disease, major depressive disorder, and heart attack. Stress hollows out our bones and atrophies our muscles. It triggers adult onset diabetes and is a leading cause of male impotence. In fact, numerous studies of human longevity in developed coun- tries have found that "psychosocial" factors such as stress are the single most important variable in determining the length of a life. It's not that genes and risk factors like smoking don't matter. It's that our levels of stress matter more.

Furthermore, the effects of chronic stress directly counteract improvements in medical care and public health. Antibiotics, for instance, are far less effective when our immune system is suppressed by stress; that fancy heart surgery will work only if the patient can learn to shed stress. As Sapolsky notes, "You can give a guy a drug-coated stent, but if you don't fix the stress problem, it won't really matter. For so many conditions, stress is the major long-term risk factor. Everything else is a short-term fix."

The emergence of stress as a major risk factor is largely a testament to scientific progress: The deadliest diseases of the 21st century are those in which damage accumulates steadily over time. (Sapolsky refers to this as the "luxury of slowly falling apart.") Unfortunately, this is precisely the sort of damage that's exacerbated by emotional stress. While modern medicine has made astonishing progress in treating the fleshy machine of the body, it is only beginning to grapple with those misfortunes of the mind that undo our treatments.

The power of this new view of stress--that our physical health is strongly linked to our emotional state--is that it connects a wide range of scientific observations, from the sociological to the molecular. On one hand, stress can be described as a cultural condition, a byproduct of a society that leaves some people in a permanent state of stress. But that feeling can also be measured in the blood and urine, quantified in terms of glucocorticoids and norepinephrine and adrenal hormones. And now we can see, with scary precision, the devastating cascade unleashed by these chemicals. The end result is that stress is finally being recognized as a critical risk factor, predicting an ever larger percentage of health outcomes.

There's a lot more in the article. Here's one example of how stress destroys the body. Elissa Epel, a former grad student of Sapolsky's and a professor of psychiatry at UCSF, has demonstrated that mothers caring for chronically ill report much higher levels of stress. That's not surprising. What is surprising is that these women also have dramatically shortened telomeres, those caps on the end of chromosomes that keep our DNA from disintegrating. (Women with the highest levels of stress had telomere shortening equal "to at least one decade of additional aging.") When our telomeres run out, our cells stop dividing; we've run out of life. Stress makes us run out of life faster.

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http://feedproxy.google.com/%7Er/scienceblogs/wDAM/%7E3/Hv0Ld6Pgzwk/smart_babies.php Smart Babies http://feedproxy.google.com/%7Er/scienceblogs/wDAM/%7E3/Hv0Ld6Pgzwk/smart_babies.php Over at Sciam's Mind Matters, Melody Dye has a great post on the surprising advantages of thinking like a baby. At first glance, this might seem like a ridiculous conjecture: A baby, after all, is missing most of the capabilities that define the human mind, such as language and the ability to reason or focus. Rene Descartes argued that the young child was entirely bound by sensation, hopelessly trapped in the confusing rush of the here and now. A newborn, in this sense, is just a lump of need, a bundle of reflexes that can only eat and cry. To think like a baby is to not think at all.

And yet, Dye notes that the very neural features that make babies so babyish might also allow them to learn about the world at an accelerated rate. Consider, for instance, the lack of a prefrontal cortex (PFC), which is woefully underdeveloped in infants. (Your PFC isn't fully developed until late adolescence.) One of the main consequences of not having an online PFC is that babies can't focus their attention. Alison Gopnik, a UC-Berkeley psychologist who has written a few wonderful books on baby cognition, suggests the following metaphor: If attention works like a narrow spotlight in adults - a focused beam illuminating particular parts of reality - then in babies it works more like a lantern, casting a diffuse radiance on their surroundings.

The lantern mode of attention can make babies seem very peculiar. For example, when preschoolers are shown a photograph of someone - let's call her Jane - looking at a picture of a family, they make very different assumptions about Jane's state of mind. When the young children are asked questions about what Jane is paying attention to, the kids quickly agree that Jane is thinking about the people in the picture. But they also insist that she's thinking about the picture frame, and the wall behind the picture, and the chair lurking in her peripheral vision. In other words, they believe that Jane is attending to whatever she can see.

While this less focused form of attention makes it more difficult to stay on task - preschoolers are easily distracted - it also comes with certain advantages. In many circumstances, the lantern mode of attention can actually lead to improvements in memory, especially when it comes to recalling information that seemed incidental at the time. This suggests that the so-called deficits of the baby brain are actually advantages, and might be there by design. Here's Dye:

The superiority of children's convention learning has been revealed in a series of ingenious studies by psychologists Carla Hudson-Kam and Elissa Newport, who tested how children and adults react to variable and inconsistent input when learning an artificial language. Strikingly, Hudson-Kam and Newport found that while children tended to ignore "noise" in the input, systematizing any variations they were exposed to, adults did just the opposite, and reproduced the variability they encountered.

So, for example, if subjects heard "elle va à la fac" 60% of the time and "elle va à fac" 40% of the time, adult learners tended to probability match and include "la" about 60% of the time, whereas younger learners tended to maximize and include "la" all of the time. While younger learners found the most consistent patterns in what they heard, and then conventionalized them, the adults simply reproduced what they heard. In William James' terms, the children made sense of the "blooming, buzzing confusion" they were exposed to in the experiment, whereas the adults did not.

Children's inability to filter their learning allows them to impose order on variable, inconsistent input, and this appears to play a crucial part in the establishment of stable linguistic norms. Studies of deaf children have shown that even when parental attempts at sign are error-prone and inconsistent, children still extract the conventions of a standard sign language from them. Indeed, the variable patterns produced by parents who learn sign language offers insight into what might happen if children did not maximize in learning: language, as a system, would become less conventional. What words meant and the patterns in which they were used would become more idiosyncratic and unstable, and all languages would begin to resemble pidgins.

Or consider this experiment, designed by John Hagen, a developmental psychologist at the University of Michigan. A child is given a deck of cards and shown two cards at a time. The child is told to remember the card on the right and to ignore the card on the left. Not surprisingly, older children and adults are much better at remembering the cards they were told to focus on, since they're able to direct their attention. However, young children are often better at remembering the cards on the left, which they were supposed to ignore. The lantern casts its light everywhere.

And it's not just complex learning that benefits from a quiet PFC. A recent brain scanning experiment by researchers at Johns Hopkins University found that jazz musicians in the midst of improvisation - they were playing a specially designed keyboard in a brain scanner - showed dramatically reduced activity in a part of the prefrontal cortex. It was only by "deactivating" this brain area - inhibiting their inhibitions, so to speak - that the musicians were able to spontaneously invent new melodies. The scientists compare this unwound state of mind with that of dreaming during REM sleep, meditation, and other creative pursuits, such as the composition of poetry. But it also resembles the thought process of a young child, albeit one with musical talent. Baudelaire was right: "Genius is nothing more nor less than childhood recovered at will."

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http://feedproxy.google.com/%7Er/scienceblogs/wDAM/%7E3/n4lwQf_DNA4/political_dissonance.php Political Dissonance http://feedproxy.google.com/%7Er/scienceblogs/wDAM/%7E3/n4lwQf_DNA4/political_dissonance.php Joe Keohane has a fascinating summary of our political biases in the Boston Globe Ideas section this weekend. It's probably not surprising that voters aren't rational agents, but it's always a little depressing to realize just how irrational we are. (And it's worth pointing out that this irrationality applies to both sides of the political spectrum.) We cling to mistaken beliefs and ignore salient facts. We cherry-pick our information and vote for people based on an inexplicable stew of superficial hunches, stubborn ideologies and cultural trends. From the perspective of the human brain, it's a miracle that democracy works at all. Here's Keohane:

A striking recent example was a study done in the year 2000, led by James Kuklinski of the University of Illinois at Urbana-Champaign. He led an influential experiment in which more than 1,000 Illinois residents were asked questions about welfare -- the percentage of the federal budget spent on welfare, the number of people enrolled in the program, the percentage of enrollees who are black, and the average payout. More than half indicated that they were confident that their answers were correct -- but in fact only 3 percent of the people got more than half of the questions right. Perhaps more disturbingly, the ones who were the most confident they were right were by and large the ones who knew the least about the topic. (Most of these participants expressed views that suggested a strong antiwelfare bias.)

Studies by other researchers have observed similar phenomena when addressing education, health care reform, immigration, affirmative action, gun control, and other issues that tend to attract strong partisan opinion. Kuklinski calls this sort of response the "I know I'm right" syndrome, and considers it a "potentially formidable problem" in a democratic system. "It implies not only that most people will resist correcting their factual beliefs," he wrote, "but also that the very people who most need to correct them will be least likely to do so."

In How We Decide, I discuss the mental mechanisms behind these flaws, which are ultimately rooted in cognitive dissonance:

Partisan voters are convinced that they're rational⎯only the other side is irrational⎯but we're actually rationalizers. The Princeton political scientist Larry Bartels analyzed survey data from the 1990's to prove this point. During the first term of Bill Clinton's presidency, the budget deficit declined by more than 90 percent. However, when Republican voters were asked in 1996 what happened to the deficit under Clinton, more than 55 percent said that it had increased. What's interesting about this data is that so-called "high-information" voters⎯these are the Republicans who read the newspaper, watch cable news and can identify their representatives in Congress⎯weren't better informed than "low-information" voters. According to Bartels, the reason knowing more about politics doesn't erase partisan bias is that voters tend to only assimilate those facts that confirm what they already believe. If a piece of information doesn't follow Republican talking points⎯and Clinton's deficit reduction didn't fit the "tax and spend liberal" stereotype⎯then the information is conveniently ignored. "Voters think that they're thinking," Bartels says, "but what they're really doing is inventing facts or ignoring facts so that they can rationalize decisions they've already made." Once we identify with a political party, the world is edited so that it fits with our ideology.

At such moments, rationality actually becomes a liability, since it allows us to justify practically any belief. We use the our fancy brain as an information filter, a way to block-out disagreeable points of view. Consider this experiment, which was done in the late 1960's, by the cognitive psychologists Timothy Brock and Joe Balloun. They played a group of people a tape-recorded message attacking Christianity. Half of the subjects were regular churchgoers while the other half were committed atheists. To make the experiment more interesting, Brock and Balloun added an annoying amount of static⎯a crackle of white noise⎯to the recording. However, they allowed listeners to reduce the static by pressing a button, so that the message suddenly became easier to understand. Their results were utterly predicable and rather depressing: the non-believers always tried to remove the static, while the religious subjects actually preferred the message that was harder to hear. Later experiments by Brock and Balloun demonstrated a similar effect with smokers listening to a speech on the link between smoking and cancer. We silence the cognitive dissonance through self-imposed ignorance.

There is no cure for this ideological irrationality - it's simply the way we're built. Nevertheless, I think a few simple fixes could dramatically improve our political culture. We should begin by minimizing our exposure to political pundits. The problem with pundits is best illustrated by the classic work of Philip Tetlock, a psychologist at UC-Berkeley. (I've written about this before on this blog.) Starting in the early 1980s, Tetlock picked two hundred and eighty-four people who made their living "commenting or offering advice on political and economic trends" and began asking them to make predictions about future events. He had a long list of questions. Would George Bush be re-elected? Would there be a peaceful end to apartheid in South Africa? Would Quebec secede from Canada? Would the dot-com bubble burst? In each case, the pundits were asked to rate the probability of several possible outcomes. Tetlock then interrogated the pundits about their thought process, so that he could better understand how they made up their minds. By the end of the study, Tetlock had quantified 82,361 different predictions.

After Tetlock tallied up the data, the predictive failures of the pundits became obvious. Although they were paid for their keen insights into world affairs, they tended to perform worse than random chance. Most of Tetlock's questions had three possible answers; the pundits, on average, selected the right answer less than 33 percent of the time. In other words, a dart-throwing chimp would have beaten the vast majority of professionals.

So those talking heads on television are full of shit. Probably not surprising. What's much more troubling, however, is that they've become our model of political discourse. We now associate political interest with partisan blowhards on cable TV, these pundits and consultants and former politicians who trade facile talking points. Instead of engaging with contrary facts, the discourse has become one big study in cognitive dissonance. And this is why the predictions of pundits are so consistently inaccurate. Unless we engage with those uncomfortable data points, those stats which suggest that George W. Bush wasn't all bad, or that Obama isn't such a leftist radical, then our beliefs will never improve. (It doesn't help, of course, that our news sources are increasingly segregated along ideological lines.) So here's my theorem: The value of a political pundit is directly correlated with his or her willingness to admit past error. And when was the last time you heard Karl Rove admit that he was wrong?

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http://feedproxy.google.com/%7Er/scienceblogs/cognitivedaily/%7E3/JhPszBY14qs/cognitive_daily_closes_shop_af.php Cognitive Daily Closes Shop after a Fantastic Five-Year Run http://feedproxy.google.com/%7Er/scienceblogs/cognitivedaily/%7E3/JhPszBY14qs/cognitive_daily_closes_shop_af.php Five years ago today, we made the first post that would eventually make its way onto a blog called Cognitive Daily. We thought we were keeping notes for a book, but in reality we were helping build a network that represented a new way of sharing psychology with the world. Cognitive Daily wasn't the first psychology blog, but clearly it filled an important niche, because within a year, we were receiving over 30,000 page views a month. Now we often get over 100,000 page views a month, and we've totaled over four million. We reach many more people than would ever have bought our book, and we've made many people aware that psychology is much more than Sigmund Freud.

Now, it's time to say goodbye to that. We are permanently closing Cognitive Daily, and this will be our last post.

While we won't be here, we've seen a number of exceptional psychology blogs join us in sharing the science of psychology with the world, and we encourage you to visit them. Rather than single any of these blogs out, we ask that you visit Dave's ongoing project, ResearchBlogging.org. There, by clicking on the "Psychology" and "Neuroscience" channels, you can find nearly 100 blogs that regularly discuss peer-reviewed research in the same fields we've been covering here. You can also follow dedicated psychology and neuroscience RSS feeds, or the @researchblogs twitter feed, to get an even broader view of what's going on in the world of science.

We're grateful to many, many people who have helped make Cognitive Daily great. There are too many to mention by name, but without the many scientists who provided the raw materials, the bloggers who've helped share ideas, and the administrators and techies who've made it all work, this blog simply couldn't exist. And, of course, without our readers and commenters, Cognitive Daily probably wouldn't have been around for more than a few months. You've inspired us, motivated us, corrected us, disputed us, informed us, and responded to more polls and surveys than we ever imagined possible. We hope you'll continue to find Cognitive Daily useful; the archives will remain here for all to see.

What will we do with all that time we've freed up? Greta plans to continue her work as Professor of Psychology at Davidson College, teaching and mentoring students, conducting research, and sharing her love of music, literature, and art. Dave will continue as editor of ResearchBlogging.org and weekly columnist for SEEDMAGAZINE.COM, and he'll maintain his personal blog, Word Munger and his obsessively-updated Twitter account. In addition, Dave's planning a new project, to be unveiled within the next few weeks. Look for more information about it on Twitter and Word Munger. In addition, Dave's now launched a new blog, The Daily Monthly. Check there for a new post every day, a new topic each month.

Thanks again for being a part of Cognitive Daily. It's been an amazing ride.

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http://feedproxy.google.com/%7Er/scienceblogs/cognitivedaily/%7E3/_8nW_dF6FGQ/bitonality.php Both musicians and non-musicians can perceive bitonality http://feedproxy.google.com/%7Er/scienceblogs/cognitivedaily/%7E3/_8nW_dF6FGQ/bitonality.php Take a listen to this brief audio clip of "Unforgettable."

Aside from the fact that it's a computer-generated MIDI performance, do you hear anything unusual?

If you're a non-musician like me, you might not have noticed anything. It sounds basically like the familiar song, even though the synthesized sax isn't nearly as pleasing as the familiar Nat King Cole version of the song. But most trained musicians can't listen to a song like this without cringing. Why? Because the music has been made "bitonal" by moving the accompanying piano part up two semitones (a semitone is the difference between a "natural" note and a sharp or flat). Here's the original, unaltered piece:

Can you tell the difference? A 2000 study led by R.S. Wolpert found that non-musicians couldn't distinguish between monotonal and bitonal music played side-by-side. Meanwhile musicians found artificially-created bitonal music to be almost unlistenable. For most non-musicians, if they heard anything wrong with the clips, they typically said they were being played too fast, or mentioned some other unrelated concept.

But Mayumi Hamamoto, Mauro Bothelo, and Margaret Munger (AKA Greta) wondered if years of musical training were really necessary for non-musicians to hear bitonal music. Bitonality is actually a bit controversial in the world of music, and it can be a little hard to define. In principle, there's a difference between bitonality and just playing or singing off-key, but in practice, the difference may not even exist. Advocates of bitonality like to point to the works of composers like Milhaud, Bartók, Prokofiev, and Strauss. These composers deliberately wrote in two different musical keys. But how is that different from occasionally or regularly writing dissonant chords? After all, all the same notes can be written using any musical key. To be truly bitonal, advocates say the two separate parts must unfold independently in different keys. This results in a distinctive "crunch" when the music is played. The separate question is, is this noticeable? Wolpert's work shows that it is, at least for trained musicians.

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http://feedproxy.google.com/%7Er/scienceblogs/cognitivedaily/%7E3/KjiY0dnqXic/synesthesia_and_the_mcgurk_eff.php Synesthesia and the McGurk effect http://feedproxy.google.com/%7Er/scienceblogs/cognitivedaily/%7E3/KjiY0dnqXic/synesthesia_and_the_mcgurk_eff.php ResearchBlogging.orgWe've discussed synesthesia many times before on Cognitive Daily -- it's the seemingly bizarre phenomenon when one stimulus (e.g. a sight or a sound) is experienced in multiple modalities (e.g. taste, vision, or colors). For example, a person might experience a particular smell whenever a given word or letter is seen or heard. Sometimes particular faces are associated with specific colors or auras. Synesthesia is relatively rare, but the people who experience it are genuine: their perceptions are consistent and replicable.

But one question researchers haven't been able to nail down is exactly how synesthesia occurs. Consider the relatively common form of synesthesia, where colors are perceived along with words. One synesthete consistently sees the color green when she hears someone say "neat." Does the synesthetic experience occur when she first detects the word, or only after she understands its meaning?

A team led by Gary Bargary has figured out a new way to test when a synesthetic experience occurs by relying on the McGurk Effect. In the McGurk effect, the word you "hear" someone saying changes depending on what you see. This movie gives a quick demonstration of the phenomenon:

In the first clip, I superimposed the sound of myself saying "neat neat peat peat" over video of myself saying "neat peat neat peat". What most people think they hear is "neat meat peat peat." You can see the actual recording of what I said in the second part of the clip. Because my mouth makes a similar movement when I say "p" and "m", the combination of the audio "neat" with a video "peat" makes viewers think they heard "meat." Listeners use both the audio and video information to decide what I'm saying, and they get it wrong! Did you experience the illusion? Let's make this a poll:

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http://feedproxy.google.com/%7Er/scienceblogs/cognitivedaily/%7E3/2_mj9NZoARs/does_tv-watching_really_kill_y.php Does watching TV really kill you? http://feedproxy.google.com/%7Er/scienceblogs/cognitivedaily/%7E3/2_mj9NZoARs/does_tv-watching_really_kill_y.php ResearchBlogging.orgToday I had to put off my normal morning run in order to make time to be interviewed on a radio show at 7:30 a.m. As I waited on hold for the interview to start, I could hear the hosts joking back-and-forth about what the "latest TV controversy" is. "Is it the Jay Leno / Conan O'Brien news on NBC?" the host asked? No. Then the hosts rattled through several other hot-button issues on television before arriving at this: "New research from the American Heart Association Journal [Circulation] suggests that watching TV might actually reduce how long you live." How's that for a controversy?

The host, John Hockenberry of The Takeaway, then introduced the lead author of the study in question, David Dunstan, and me, and asked us to explain how watching TV may or may not result in death. Dunstan's team's study, as you might expect, has gotten a lot of media attention. There was a press release, a report on CNN, and many others. It was nearly midnight in Dunstan's home in Australia, and he had been taking interviews all day.

I had been selected as a commentator because of my column a few weeks ago on SEEDMAGAZINE.COM where I discuss the harms and benefits of TV. So, presumably, my "pro-TV" viewpoint would balance Dunstan's "anti-TV" research.

But for the most part, science doesn't lend itself to this sort of position-taking. We can understand the results of a study, and perhaps do a bit of speculating on the implications, but beyond that there really isn't much room for taking sides. So let's take a closer look at the study in question.

Dunstan's team analyzed data from the massive AusDiab study of diabetes and related diseases in Australia. In 1999 and 2000, researchers visited over 28,000 randomly-selected Australian households to gather medical and other data, to be revisited over many years following. For this study, the researchers identified 8,800 adults who met their criteria for participation (basically, they showed no signs of cardiovascular disease, they completed the entire response form and medical tests, and their results fell in a normal range). Then they observed who died over the next six to seven years, a total of 284 individuals.

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http://feedproxy.google.com/%7Er/scienceblogs/cognitivedaily/%7E3/Pkc0z0tjnT4/how_baseball_and_softball_outf.php The outfielder problem: The psychology behind catching fly balls http://feedproxy.google.com/%7Er/scienceblogs/cognitivedaily/%7E3/Pkc0z0tjnT4/how_baseball_and_softball_outf.php ResearchBlogging.orgIt's football season in America: The NFL playoffs are about to start, and tonight, the elected / computer-ranked top college team will be determined. What better time than now to think about ... baseball! Baseball players, unlike most football players, must solve one of the most complicated perceptual puzzles in sports: how to predict the path of a moving target obeying the laws of physics, and move to intercept it.

The question of how a baseball player knows where to run in order to catch a fly ball has baffled psychologists for decades. (You might argue that a football receiver faces a similar task, but generally in football, the distances involved are much shorter, and most football players aren't expected to catch passes at all.)

There are three primary possible explanations for how a baseball fielder catches a fly ball:

  • Trajectory Projection (TP): The fielder calculates the trajectory of a ball the moment it is hit and simply runs to the spot where it will fall (of course, taking into account wind speed and barometric pressure).
  • Optical acceleration cancellation (OAC): The fielder watches the flight of the ball; constantly adjusting her position in response to what she sees. If it appears to be accelerating upward, she moves back. If it seems to be accelerating downward, she moves forward.
  • Linear optical trajectory (LOT): The fielder pays attention to the apparent angle formed by the ball, the point on the ground beneath the ball, and home plate, moving to keep this angle constant until she reaches the ball. In other words, she tries to move so that the ball appears to be moving in a straight line rather than a parabola.

In principle, all three of these systems should work. However, TP is probably impossible; our visual system isn't accurate at determining distances beyond about 30 meters, and outfielders stand up to 100 meters away from home plate. The second system, OAC, might not work because the visual system isn't actually very sensitive to acceleration. And the third system, LOT, is problematic because it doesn't predict a unique path for the fielder to take to the ball. Further, the most likely paths a fielder would take to catch a ball wouldn't be much different under OAC and LOT.

But Philip Fink, Patrick Foo, and William Warren figured out a way to experimentally distinguish between all three models. They had 8 skilled male baseball players and 4 skilled female softball players don VR headsets and attempt to catch virtual balls in a large room. The room was big enough that they could freely move 6 meters in each direction. VR was necessary because the researchers made their virtual balls take paths that aren't possible in real life:

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http://www.nimh.nih.gov/science-news/2012/gene-regulator-in-brains-executive-hub-tracked-across-lifespan-nih-study.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary Science News » Gene Regulator in Brain’s Executive Hub Tracked Across Lifespan – NIH study http://www.nimh.nih.gov/science-news/2012/gene-regulator-in-brains-executive-hub-tracked-across-lifespan-nih-study.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary http://www.nimh.nih.gov/about/director/2012/the-long-paths-to-breakthroughs.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary Blog Post » The Long Paths to Breakthroughs http://www.nimh.nih.gov/about/director/2012/the-long-paths-to-breakthroughs.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary http://www.nimh.nih.gov/about/director/2012/balancing-immediate-needs-with-future-innovation.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary Blog Post » Balancing Immediate Needs with Future Innovation http://www.nimh.nih.gov/about/director/2012/balancing-immediate-needs-with-future-innovation.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary http://www.nimh.nih.gov/science-news/2012/ethnic-disparities-persist-in-depression-diagnosis-and-treatment-among-older-americans.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary Science News » Ethnic Disparities Persist in Depression Diagnosis and Treatment Among Older Americans http://www.nimh.nih.gov/science-news/2012/ethnic-disparities-persist-in-depression-diagnosis-and-treatment-among-older-americans.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary http://www.nimh.nih.gov/news/media/audio/2011-society-for-neuroscience-conference-highlights.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary Audio » 2011 Society for Neuroscience Conference Highlights http://www.nimh.nih.gov/news/media/audio/2011-society-for-neuroscience-conference-highlights.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary